医師紹介

経歴

2002年

獨協医科大学卒業。医師免許取得

2004年

日本大学医学部内科研修終了

2004年

順天堂大学心臓血管外科入局(2011年順天堂大学大学院博士課程修了。博士号取得)

2007年

ニューヨーク・コロンビア大学循環器内科 Post doctoral research fellow

2012年

ニューヨーク・コロンビア大学心臓血管外科 Associate research scientist

2013年～2021年

江戸川病院消化器外科勤務

2021年4月現在

順天堂大学心臓血管外科　非常勤助教

所属学会・資格

• 医学博士
• 日本外科学会・外科専門医
• 日本消化器外科学会
• 港区医師会会員
• 認知症サポート医

論文

• Left ventricular assist device-acquired aortic insufficiency.
  Akashi H.
  Circ J. 2015;79(1):43-4. doi: 10.1253/circj.CJ-14-1302. Epub 2014 Dec 12.
  PMID: 25501950 No abstract available.
• Activin type II receptor ligand signaling inhibition after experimental ischemic heart failure attenuates cardiac remodeling and prevents fibrosis.
  Castillero E, Akashi H, Najjar M, Ji R, Brandstetter LM, Wang C, Liao X, Zhang X, Sperry A, Gailes M, Guaman K, Recht A, Schlosberg I, Sweeney HL, Ali ZA, Homma S, Colombo PC, Ferrari G, Schulze PC, George I. Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H378-H390. doi: 10.1152/ajpheart.00302.2019. Epub 2019 Dec 30.
  PMID: 31886717 Free PMC article.
• Increased de novo ceramide synthesis and accumulation in failing myocardium.
  Ji R, Akashi H, Drosatos K, Liao X, Jiang H, Kennel PJ, Brunjes DL, Castillero E, Zhang X, Deng LY, Homma S, George IJ, Takayama H, Naka Y, Goldberg IJ, Schulze PC.
  JCI Insight. 2017 Jul 20;2(14):e96203. doi: 10.1172/jci.insight.96203. eCollection 2017 Jul 20. PMID: 28724803 Free PMC article. No abstract available.
• Increased de novo ceramide synthesis and accumulation in failing myocardium.
  Ji R, Akashi H, Drosatos K, Liao X, Jiang H, Kennel PJ, Brunjes DL, Castillero E, Zhang X, Deng LY, Homma S, George IJ, Takayama H, Naka Y, Goldberg IJ, Schulze PC.
  JCI Insight. 2017 May 4;2(9):e82922. doi: 10.1172/jci.insight.82922. eCollection 2017 May 4.
  PMID: 28469091 Free PMC article.
• Continuous-flow left ventricular assist device exchange: clinical outcomes.
  Ota T, Yerebakan H, Akashi H, Takayama H, Uriel N, Colombo PC, Jorde UP, Naka Y.
  J Heart Lung Transplant. 2014 Jan;33(1):65-70. doi: 10.1016/j.healun.2013.07.003. Epub 2013 Aug 9.
  PMID: 23937885
• Prognostic scoring systems for patient evaluation before left ventricular assist device implantation.
  Akashi H, Schulze PC.
  Circ J. 2012;76(8):1828-9. doi: 10.1253/circj.cj-12-0792. Epub 2012 Jul 4.
  PMID: 22785556 No abstract available.
• Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery.
  Castillero E, Ali ZA, Akashi H, Giangreco N, Wang C, Stöhr EJ, Ji R, Zhang X, Kheysin N, Park JS, Hegde S, Patel S, Stein S, Cuenca C, Leung D, Homma S, Tatonetti NP, Topkara VK, Takeda K, Colombo PC, Naka Y, Sweeney HL, Schulze PC, George I.
  Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1463-H1476. doi: 10.1152/ajpheart.00187.2018. Epub 2018 Aug 24.
  PMID: 30141986 Free PMC article.
• Feasibility and safety of continuous retrograde administration of Del Nido cardioplegia: a case series.
  Najjar M, George I, Akashi H, Nishimura T, Yerebakan H, Mongero L, Beck J, Hill SC, Takayama H, Williams MR.
  J Cardiothorac Surg. 2015 Nov 26;10:176. doi: 10.1186/s13019-015-0383-x.
  PMID: 26612068 Free PMC article.
• Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia.
  Son NH, Ananthakrishnan R, Yu S, Khan RS, Jiang H, Ji R, Akashi H, Li Q, O'Shea K, Homma S, Goldberg IJ, Ramasamy R.
  PLoS One. 2012;7(9):e46549. doi: 10.1371/journal.pone.0046549. Epub 2012 Sep 27.
  PMID: 23029549 Free PMC article.
• Vascular inflammation and abnormal aortic histomorphometry in patients after pulsatile- and continuous-flow left ventricular assist device placement.
  Lee M, Akashi H, Kato TS, Takayama H, Wu C, Xu K, Collado E, Weber MP, Kennel PJ, Brunjes DL, Ji R, Naka Y, George I, Mancini D, Farr M, Schulze PC.
  J Heart Lung Transplant. 2016 Sep;35(9):1085-91. doi: 10.1016/j.healun.2015.12.027. Epub 2016 Jan 6.
  PMID: 26899764 Free PMC article.
• Outcome of patients with cardiac sarcoidosis undergoing cardiac transplantation--single-center retrospective analysis.
  Akashi H, Kato TS, Takayama H, Naka Y, Farr M, Mancini D, Schulze PC.
  J Cardiol. 2012 Nov;60(5):407-10. doi: 10.1016/j.jjcc.2012.07.013. Epub 2012 Aug 11.
  PMID: 22890069
• Attenuation of the unfolded protein response and endoplasmic reticulum stress after mechanical unloading in dilated cardiomyopathy.
  Castillero E, Akashi H, Pendrak K, Yerebakan H, Najjar M, Wang C, Naka Y, Mancini D, Sweeney HL, D Armiento J, Ali ZA, Schulze PC, George I.
  Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H459-70. doi: 10.1152/ajpheart.00056.2015. Epub 2015 Jun 8. PMID: 26055788 Free PMC article.
• Effects of continuous-flow versus pulsatile-flow left ventricular assist devices on myocardial unloading and remodeling.
  Kato TS, Chokshi A, Singh P, Khawaja T, Cheema F, Akashi H, Shahzad K, Iwata S, Homma S, Takayama H, Naka Y, Jorde U, Farr M, Mancini DM, Schulze PC.
  Circ Heart Fail. 2011 Sep;4(5):546-53. doi: 10.1161/CIRCHEARTFAILURE.111.962142. Epub 2011 Jul 15.
  PMID: 21765125 Free PMC article.
• Role of biofilm in Staphylococcus aureus and Staphylococcus epidermidis ventricular assist device driveline infections.
  Toba FA, Akashi H, Arrecubieta C, Lowy FD.
  J Thorac Cardiovasc Surg. 2011 May;141(5):1259-64. doi: 10.1016/j.jtcvs.2010.07.016. Epub 2010 Aug 14.
  PMID: 20709333 Free PMC article.
• Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy.
  Castillero E, Akashi H, Wang C, Najjar M, Ji R, Kennel PJ, Sweeney HL, Schulze PC, George I.
  Biochem Biophys Res Commun. 2015 Jan 30;457(1):106-11. doi: 10.1016/j.bbrc.2014.12.057. Epub 2014 Dec 18.
  PMID: 25528587 Free PMC article.
• Supplementation of l-Alanyl-l-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chronic Heart Failure.
  Wu C, Kato TS, Ji R, Zizola C, Brunjes DL, Deng Y, Akashi H, Armstrong HF, Kennel PJ, Thomas T, Forman DE, Hall J, Chokshi A, Bartels MN, Mancini D, Seres D, Schulze PC.
  Circ Heart Fail. 2015 Nov;8(6):1077-87. doi: 10.1161/CIRCHEARTFAILURE.115.002073. Epub 2015 Aug 12.
  PMID: 26269566 Free PMC article. Clinical Trial.
• SdrF, a Staphylococcus epidermidis surface protein, contributes to the initiation of ventricular assist device driveline-related infections.
  Arrecubieta C, Toba FA, von Bayern M, Akashi H, Deng MC, Naka Y, Lowy FD.
  PLoS Pathog. 2009 May;5(5):e1000411. doi: 10.1371/journal.ppat.1000411. Epub 2009 May 1.
  PMID: 19412528 Free PMC article.
• Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction.
  Zizola C, Kennel PJ, Akashi H, Ji R, Castillero E, George I, Homma S, Schulze PC.
  Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1078-85. doi: 10.1152/ajpheart.00679.2014. Epub 2015 Feb 20.
  PMID: 25713305 Free PMC article.
• Markers of extracellular matrix turnover and the development of right ventricular failure after ventricular assist device implantation in patients with advanced heart failure.
  Kato TS, Chokshi A, Singh P, Khawaja T, Iwata S, Homma S, Akashi H, Cheema F, Yang J, Takayama H, Naka Y, Farr M, Mancini D, Schulze PC.
  J Heart Lung Transplant. 2012 Jan;31(1):37-45. doi: 10.1016/j.healun.2011.10.007. Epub 2011 Nov 9.
  PMID: 22071239
• Increased levels of retinol binding protein 4 in patients with advanced heart failure correct after hemodynamic improvement through ventricular assist device placement.
  Chavarria N, Kato TS, Khan R, Chokshi A, Collado E, Akashi H, Takayama H, Naka Y, Farr M, Mancini D, Schulze PC.
  Circ J. 2012;76(9):2148-52. doi: 10.1253/circj.cj-12-0350. Epub 2012 Jun 12.
  PMID: 22785609 Clinical Trial.
• Development of a murine ventricular assist device transcutaneous drive-line model.
  von Bayern MP, Arrecubieta C, Oz S, Akashi H, Cedeiras M, Naka Y, Deng MC, Lowy FD.
  J Heart Lung Transplant. 2008 Jul;27(7):812-4. doi: 10.1016/j.healun.2008.04.003. Epub 2008 Jun 2.
  PMID: 18582816 Free PMC article. No abstract available.
• Myocardial protection using del nido cardioplegia solution in adult reoperative aortic valve surgery.
  Sorabella RA, Akashi H, Yerebakan H, Najjar M, Mannan A, Williams MR, Smith CR, George I.
  J Card Surg. 2014 Jul;29(4):445-9. doi: 10.1111/jocs.12360. Epub 2014 May 26.
  PMID: 24861160 Free PMC article.

監訳

• 書名：心臓手術の周術期管理
  出版社：株式会社　メディカル・サイエンス・インターナショナル
  刊行年月：2008年1月1日
  ISBN：978-4-89592-497-9
  詳細はこちら